Wednesday October 31, 2007
Epinephrine for septick shock: Why not ?


"............................

In my practice, I use epinehrine as a first line agent vasopressor. It is 10 times cheaper than Norepinehrine (in my country) and also provides cardiac support for which I don't have to worry about dobutamine or close followup of cardiac index. No single study has ever shown that which vasopressor is superior. Epinephrine for septick shock: Why not ?"


Djillali Annane,

Yesterday while speaking at Canada Critical Care Forum annual meeting at Toronto, Canada. www.criticalcarecanada.com

Tuesday October 30, 2007



Q: what is "cryo reduced plasma"?

A; One unit of cryoprecipitate is derived from one unit of fresh frozen plasma (FFP). Left over FFP, after removal of cryoprecipitate is called supernatant plasma or CRYO-REDUCED PLASMA.


Clinical Significance: Cryo-reduced plasma is used as a treatment in plasmapheresis for TTP, not responding to regular plasma exchange with FFP. Some physicians even use it as first line for plasmapheresis/Therapeutic Plasma Exchange (TPE) for a patient with Thrombotic Thrombocytopenic Purpura (TTP).

Monday October 29, 2007
Hydrocortisone and Dexamethasone


What are the 3 major differences between Hydrocortisone and Dexamethasone ?

1. Potency of Hydrocortisone and Dexamethasone is 20:1 (precisely 20 : 0.75) - means .75 mg of dexamethasone is equal to 20 mg of hydrocortisone.

2. Mineralocorticoid : Glucocorticoid activity is 1:1 in hydrocotisone but dexamethasone has negligible mineralocorticoid activity as well it does not effect cortisol level.

3. Half life of Hydrocortisone is 8-12 hrs and of dexametasone is 36-54 hrs.


See nice review Relative Adrenal Insufficiency: Case Examples & Review from Bradley J. Phillips, M.D. , Boston Medical Center, Boston Univ. Schl of Med. (ref: The Internet Journal of Endocrinology. 2005. Volume 1 Number 2)

Sunday October 28, 2007
A-line Tip


Suturing of arterial line particularly at femoral site may be tricky as catheter may get twist, turn and kink as they are relatively smaller catheter, both in length and diameter. Not only you may loose hardly obtained arterial placement but may cause significant bleeding.

Answer is simple. After you pass catheter over wire - suture first than remove the wire (if you are positive about right placement) or reinsert the wire once good pulsation of bright red blood confirmed. Some A-line kits (like arrow) have extra short wire (with J-shaped curve at back) to pass till you obtain secure placement. You must suture femoral A-lines as simple dressing will not secure it. Radial A-lines may be dressed tightly without sutures but it is preferable to secure it with sutures.



Related previous pearls:

Potassium level via A-line

A-line is here but where is Allen test !!

Ultrasound guided insertion of radial artery catheters

Saturday October 27, 2007
Digoxin Toxicity

Question: Once patient receive Digoxin Fragmented Antibody (DIGIFAB or Digibind), how frequent digoxin level should be measured ?


Answer: Digoxin level after giving Digibind will rise and will remain distorted for about 7 days. This is due to ability of Digibind to pull all of the digoxin into blood stream. These are inactive fragments and not toxic. There is no need to follow Dig level after administration of Digibind as it may be misleading.

Friday October 26, 2007

Scenario: 48 year old male, hemodialysis dependent, admitted with gastro-intestinal bleed. Last dialysis was 3 days ago. Patient received 4 units of pRBC and now hemodynamically stable. Nurse calls you as she felt that rhythm looks different on monitor. Patient is asymptomatic. Walking towards patient's bed what would be your top diagnosis ?

Answer: HyperkalemiaTransfusion-associated hyperkalemia is a potential life threatening condition in patients with renal failure who have not been dialysed recently or with already elevated/borderline potassium level and should be followed closely.

Thursday October 25, 2007
Adjustment of Anion Gap (AG) for albumin


A big majority of patients particularly in medical-ICU are hypoalbumenic. Albumin is a major unmeasured anion and its lower level may give false normal anion gap (means normal calculated anion gap despite actual high anion gap).

The formula to adjust anion gap with albumin is as follows

Adjusted AG = calculated AG + 2.5 (4.5 - measured albumin)

Calculated AG = Na - (Cl + HCO3)
4.5 = normal albumin level


Example: Patient has following data:

Na = 144
Cl = 102
HCO3 = 18
Albumin = 2.6

Calculated AG = 144 - (102 + 18) = 24 mEq/L

Adjusted AG = 24 + 2.5 (4.5 - 2.6) = 24 + 2.5(1.9) = 28.75 mEq/L

Reference: click to get article/abstract

Anion gap and hypoalbuminemia - Critical Care Medicine. 26(11):1807-1810, November 1998.

Wednesday October 24, 2007

Scenario: You have a patient with intracranial bleed. ICP monitor has been inserted by neurosurgical service. You have been asked by nurse to clarify confusion about the level of transducer for Mean Arterial pressure (MAP), so correct CPP (Cerebral Perfusion Pressure) can be calculated. What is the answer?



Answer: To calculate CPP, tansducer should be "zeroed" at the height of the head to calculate MAP. There is a misconception that transducer should always be leveled / zeroed at heart level. Its not true. For Cerebral Perfusion Presuure calculation, MAP should be calculated with transducer at head (or ear) level.

Cerebral Perfusion Pressure (CPP) is defined as the difference between the Mean Arterial Pressure (MAP) and the Intracranial Pressure (ICP).

CPP = MAP - ICP

Tuesday October 23, 2007
Critical Care Survey

Please help our international colleagues by completing following Critical Care survey. It is a quick 10 questions' survey of clinical practice of Critical Care Medicine at bedside, and should not take more than one minute.

Click here

(please email chackojose@gmail.com if you cannot open survey)


Survey/study conduted by

Dr. Jose Chacko,
Head of Department,
Multidisciplinary Intensive Care Unit *,
Manipal Hospital,
Bangalore, India

* 23 bedded closed unit with medical, trauma and postoperative patients with an annual admission rate of about 1200

Monday October 22, 2007


Scenario: You intubated 53 year old short female * without any complication. CXR showed ETT in right main stem. You instructed RT (Resp. Therapist) to pull ETT by 3 cm. After adjustment, patient develop significant SQ emphysema along with periorbital swelling.


Answer: Tracheal tear due to repositioning of the tube without cuff deflation !

Tracheobronchial laceration is a potential serious complication of endotracheal intubation. It can occur following uneventful intubation. Most injuries are in the lower third of the trachea .

Most common causes include:

• Overinflation of the cuff, resulting in necrosis of the mucosa after prolonged intubation
• Repositioning of the tube without cuff deflation
• Patient movement
• A sudden increase in the intratracheal pressure caused by vigorous coughing in the presence of the endotracheal tube
• Inappropriate tube size
• COPD
• Conditions associated with a weakness of the membranous trachea (eg, elderly patient, steroid therapy)
• Mucosal erosion or perforation of the anterior cartilaginous tracheal wall from the tip of the tube or the stylet.
  
  

* Almost all cases of postintubation tracheal laceration are reported in short female patients.



Reference: Click to get article/abstract

1. A 63-Year-Old Woman With Subcutaneous Emphysema Following Endotracheal Intubation - Chest. 2005;128:434-438

Sunday October 21, 2007


Re. our video pearl from yesterday - Ultrasound guided venous catheter placement , we received following feedback: Cool video and well done. Couple of comments are of sterile technique which was not followed, clorhexidine vs povidone and no time out emphasized on video. - "Luis Urrutia" urrutialuis@yahoo.com


Endotracheal intubation and common pitfalls - 2 videos

Saturday October 20, 2007
Ultrasound guided venous catheter placement - video


(click here, if you can't watch video on this page)

Friday October 19, 2007
Acute A. fib. and Digoxin


Q: 44 year old male with CHF went into Atrial fibrillation with RVR (Rapid Ventricular Rate) of 160 to 180 beats per minute. You ordered Digoxin 0.25 mg IV but after 15 minutes, there is no response ?


Answer: Digoxin is an effective medicine for control of Atrial fibrillation associated RVR particularly in patients with congestive heart failure and left ventricular systolic dysfunction. But this is of importance to know that Digoxin is not a treatment for very acute management of A.fib. The onset of action is usually at 30 minutes with a peak effect in 2 - 3 hours.

Thursday October 18, 2007
2 ways of CVP measurement

Central Venous Pressure can be measured in 2 units - cm H2O and mm Hg, depending on which system is used. CVP in ICUs is usually measured in mmHg via electronic monitor.

The conversion formula of CVP in cm H2O to mm Hg is:

10 mm H20 = 7.5 mm Hg
Or to be precise
1 mm Hg = 1.36 cm H2O

Normal CVP is 2-8 mmHg and 5 - 10 cmH2O


Here is one nice reference article on CVP, Central Venous Pressure monitoring ( Sheldon Magder, McGill University Health Centre, Division of Critical Care, Montreal, Canada - Current Opinion in Critical Care 2006, 12:000–000)

Below is the picture of manometer way of CVP measurement

Click here to go to full reference article - Measuring Central Venous Pressure from Deptt. of Anaesthesiology, Univ. of Hong Kong.

Wednesday October 17, 2007



Q; What is the physiologic amount of cortisol secreted by adrenals per day?



A; Adults secrete about 20 mg of cortisol daily.

We use anywhere from 200 - 300 mg of hydrocortisone as stress dose to encounter adrenal insufficiency. In USA, we prescribe it in divided doses and our european counterpart use it in a continuous drip and mostly along with fludrocortisone. But it may be of interest to know that physiologically, adrenal cortex in adults secrete only 20 mg of cortisol daily. It also secretes 2 mg of corticosterone which has similar activity. We use higher dose under presumption that due to stress body may require higher cortisol level. Usually, if its pure adrenal insufficiancy, restoration of BP and general improvement may be seen within 1 hour after the initial dose of hydrocortisone.

Some experts advise to leave the dose at 20 mg per day of hydrocortisone once hemodynamics are improved and stress is resolved and taper it later 1.


Related previous pearl:

Hypoproteinemia and cosyntropin test

Low dose steroid, yes or no ? - responder or non-responder ? - low-dose corticotropin stimulation test or high dose?

Hydrocortisone and Dexamethasone


Relevant study to know:

Corticus study (Corticosteroid Therapy of Septic Shock).


Reference:

1. The ICU Book : Paul L. Marino : 2nd edition: Page 770

Tuesday October 16, 2007


Q: What is your diagnosis ?

Tuesday October 16, 2007



Q: What is your diagnosis ?



Answer: Tension gastrothorax

Tension Gastrothorax is a frequent complication of trauma with diaphragmatic injury. In the spontaneously ventilating patient the negative pressure generated in the thoracic cavity progressively sucks the stomach into the chest with each breath. Eventually, respiratory and haemodynamic compromise ensue, as with a classic tension pneumothorax.

Its important to differential diagnosis from Tension Pneumothorax.

Immediate treatment is either Nasogastric tubes placement to decompress the stomach - although placement may be difficult due to difficulty in passing the diaphragm, or Positive pressure ventilation to allow immediate re-expansion of the lung which forces intraperitoneal contents back into the abdomen.

As operative repair is the eventual treatment, its better to just intubate patient.

Monday October 15, 2007
Look for leukoreduced RBCs ?

Studies after studies are now pointing towards conservative practice of transfusion in ICU. This month "Chest" has published another study to assess effect of RBC transfusion on in-hospital mortality in 248 consecutive patients with already having ALI.

Results:

• Overall in-hospital mortality rate was 39.5% (Of these patients, 207 of 248 patients received atleast 1 unit of packed RBCs
• The transfusion of any packed RBCs was associated with an increased risk of death.
• The overall OR (odds ratio) per unit was 1.06
• Transfusion after ALI onset was associated with an adjusted OR of 1.13, while transfusion before ALI onset was not associated with higher risk
• The adjusted OR per unit of nonleukoreduced RBC transfused was 1.14, while the adjusted OR for leukoreduced cells per unit transfused was 1.06

Conclusions:

• Transfusion of RBCs in patients with ALI was associated with increased in-hospital mortality.
• This risk was greater for nonleukoreduced than for leukoreduced RBCs.

Reference: click to get abstract

1. Association of RBC Transfusion With Mortality in Patients With Acute Lung Injury - Chest. October 2007; 132:1116-1123

Sunday October 14, 2007
LASA drugs

Many studies have shown so far that errors in administration of drugs remain high and actually twice in ICUs. In this regard, its important to know the term LASA medications. LASA are "look-alike sound-alike" medications and are responsible for 12.5 percent of the medication errors reported to the FDA. Other factors making it worse include illegible handwriting, look alike packaging, unclear verbal directions, similar pronunciation etc etc. We all went through the experiences of confusion between

• dopamine and dobutamine,
• phenylephrine and norepinehrine,
• heparin and hespan,
• primacor and primaxin,
• diflucan and diprivan
  

Institutions are taking initiatives like

• computer based drug entry,
• verbal read backs,
• automated alerts,
• advise to prescribers to write both the brand and generic name on problematic drugs or
• to include the intended purpose of the medication

JCAHO has now made LASA drugs part of its National Patient Safety Goals and institutions are expected to prepare organisational list of LASA drugs.Click here to read position paper on critical care pharmacy services from Society of Critical Care Medicine and American College of Clinical Pharmacy Task Force on Critical Care Pharmacy Services.



Related previous Pearls:

1. ICU satellite pharmacy
2. Preventing intra-venous (IV) drip errors
3. "Five Rights"


Reference:

Preventable adverse drug events in hospitalized patients: A comparative study of intensive care and general care units Critical Care Medicine. 25(8):1289-1297, August 1997.

Saturday October 13, 2007
Dopamine dosing on pump !


Beauty of Critical Care Medicine is in details


In contrast to dosing of other vasopressors, it is important to dose Dopamine on "ideal" body weight instead of actual body weight.

Unexpected tachycardia or hypertension may occur due to overdosing, if actual body weight instead of "ideal" body weight punched on pump. This is important to understand as in ICU it is very frequent to have high actual body weight due to fluid resuscitation. The right way to write dopamine dosing is like,

Start Dopamine drip with 2 mcg/kg/min of "Ideal" body weight and titrate as needed upto 20 mcg/kg/min. Call physician if heart rate more than 120 or Mean Blood Pressure more than 100.



Further recommended reading

1. Dopamine administration - Intensive Care Medicine , Volume 10, Number 5 / September, 1984
2. The ICU Book - 3rd edition, Paul L. Marino, Page 301

Friday October 12, 2007

Scenario: Nurse call you as patient 's SVRI (Systemic Vascular Resistance Index) is only 372. As you asked further hemodynamics data, you were given following info:

MAP (Mean Arterial Pressure) = 80 ,
CI (Cardiac Index) = 4.0,
CVP = 10

What what be your response?

1. Do Nothing - you are happy with this number
2. Recalibrate and recheck the SVRI again as it appears to be an error.
3. Titrate the vasopressor up.
4. Give fluid.
5. Give Lasix.

Answer: B

This is probably an error as formula for SVRI is

SVRI = (MAP - CVP) / CI x 80

so SVRI in above case should be:

(80 - 10)/4 x 80 = 1400

Objective of above question is to emphasize the point that, with high dependence on technology and computer chips, errors are common and its very important to obtain full picture when things appear out of normal for no reason and does not fit with full picture. It is more important to know "What not to do" than to know "what to do" !

It is very frequent in board exams to have questions with objective to identify erroneous data !

Thursday October 11, 2007
Carbon Dioxide Angiography

Carbon dioxide (CO2) gas is used as an alternative contrast to iodinated contrast material. When injected into a blood vessel, carbon dioxide bubbles displace blood, allowing vascular imaging. Because of the lack of nephrotoxicity and allergic reactions, CO2 is increasingly used as a contrast agent for diagnostic angiography and vascular interventions.

CO2 is particularly useful in patients with renal insufficiency or a history of hypersensitivity to iodinated contrast medium. Also, it is safe as CO2 is effectively eliminated by means of respiration.

Disadvantage: CO2 is less dense than iodinated contrast medium, and the overall quality of the CO2 vascular image is less than the contrast medium.


Cautions:

• CO2 should not be used as a contrast agent in the coronary and cerebral circulations because of the possibility of adverse effects secondary to a gas embolism. Safely, CO2 should be avoided in vessels above the diaphragm.
• In patients with pulmonary insufficiency or pulmonary hypertension because of amount diagnostic doses of CO2 pulmonary arterial pressure may increase.
• In right-to-left shunts Co2 may cause paradoxical gas embolism.
  
  

See slide presentation CARBON DIOXIDE ANGIOGRAPHY AND INTERVENTION CARBON DIOXIDE (Jim Caridi MD. University of Florida. Gainesville, FL)



Reference: click to get article

Carbon Dioxide Angiography - emedicine.com

Wednesday October 10, 2007
Significance of venous blood gas

Venous blood gasses are easy to obtained but very under-utilized in ICUs.

In ICU setting where hypotension and hypoperfusion are very common, it is very important to know that although information about arterial blood gases is needed to assess pulmonary gas exchange, in the presence of severe hypoperfusion, the hypercapnia and acidemia at the level of the tissues are detected better and correlate more in central venous blood.



References: click to get abstracts

Assessing acid-base status in circulatory failure. Differences between arterial and central venous blood - Volume 320:1312-1316, , May 18. 1989

Comparison of Blood Gas and Acid-Base Measurements in Arterial and Venous Blood Samples in Patients with Uremic Acidosis and Diabetic Ketoacidosis in the Emergency Room - American Journal of Nephrology 2000;20:319-323

Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate.. Emerg. Med. J. 23: 622-624

Tuesday October 9, 2007
"Locked-in" Syndrome (coma vigilante)

Patient is a silent and unresponsive witness to everything that is happening" - from story of Nick Chisholm 1


Patient with Locked-in syndrome is a fully conscious person, but all the voluntary muscles of the body are completely paralyzed, other than those that control eye movement. Term was first introduced about 25 years ago by Plum and Posner with complete occlusion of the basilar artery. 3

Locked-In syndrome can be caused by stroke at the level of the basilar artery denying blood to the ventral part of the pons, among other causes. Any catastrophy involving ventral pons can cause this syndrome like massive stroke, traumatic head injury, ruptured aneurysm, pontine infarction after prolonged vertebrobasilar ischaemia, haemorrhage, tumor, central pontine myelinolysis, pontine abscess or postinfective polyneuropathy. As all of the nerve tracts responsible for voluntary movement pass through the ventral pons but fortunately or unfortunately, consciousness are above the level of the ventral pons. 2

Only supportive rehabilitation is the answer.

Being an intensivist, it is extremely important to educate staff and to protect patient from any physical or psychological harm (like procedure without adequate analgesia), with an upmost understanding that it is an "imprisoned mind buried alive in a dead body’’ (as said for character with paralysis like locked-in syndrome in Thérèse Raquin by Emile Zola - 1868).


References: Click to get articles/abstract

1. The patient's journey: Living with locked-in syndrome - BMJ 2005;331:94-97 (9 July)
2. Locked-in Syndrome - enotes.com
3. Plum F, Posner JB. The diagnosis of stupor and coma. Philadelphia: FA Davis, 1982; 377
4. Locked-in syndrome: a catastrophic complication after surgery - British Journal of Anaesthesia, 2004, Vol. 92, No. 2 286-288

Monday October 8, 2007
Comparison of two dose regimens of arginine vasopressin in advanced vasodilatory shock.


Even though not an establish part of guidelines and literature is not plenty either, vasopressin has fastly become an integral pressor in most ICUs across USA. Usual acceptable dose is 0.04 units/min.

Very recently, a retrospective controlled study of 78 patients published, to evaluate the effects of two vasopressin dose regimens (0.033 vs. 0.067 IU/min) on treatment efficacy, hemodynamic response, prevalence of adverse events, and changes in laboratory variables.

78 patients with vasodilatory shock (mean norepinephrine dosage, 1.07 mcg//min were given supplementary infusion of vasopressin. 2 groups were

• 0.033 (n = 39) and
• 0.067 IU/min (n = 39)

Cardiocirculatory, laboratory, and clinical variables were evaluated and compared between groups before and at 0.5, 1, 4, 12, 24, 48, and 72 hrs after initiation of Vasopressin (AVP).

Treatment efficacy was assessed by the increase in mean arterial blood pressure and the extent of norepinephrine reduction during the first 24 hrs of vasopressin therapy.


Results:

• Although the relative increase in mean arterial pressure was comparable between groups (16.8 +/- 18.4 vs. 21.4 +/- 14.9 mm Hg), norepinephrine could be reduced significantly more often in patients receiving 0.067 IU/min.
• AVP at 0.067 IU/min resulted in a higher mean arterial pressure (p < .001), lower central venous pressure (p = .001), lower mean pulmonary arterial pressure (p = .04), and lower norepinephrine requirements (p < .001) during the 72-hr observation period.
• Increases in liver enzymes occurred more often in patients treated with 0.033 IU/min (71.8% vs. 28.2% - p < .001) !
• The prevalence of a decrease in cardiac index, decrease in platelet count, and increase in total bilirubin was not significantly different between groups.
• Base deficit were lower and arterial lactate concentrations higher in patients receiving 0.033 IU/min.

Conclusions: Vasopressin dosages of 0.067 IU/min seem to be more effective to reverse cardiovascular failure in vasodilatory shock requiring high norepinephrine dosages than 0.033 IU/min.



Reference: click to get abstract/article

Comparison of two dose regimens of arginine vasopressin in advanced vasodilatory shock. - Critical Care Medicine. 35(10):2280-2285, October 2007.

Sunday October 7, 2007
Carvedilol (Coreg)



Q: How Carvedilol (Coreg) is different from other B-blockers?

A; Coreg is a triple blocker. It blocks beta-1, beta-2 and alpha-1 receptors. Alpha-1 blockade provides vasodilation and so protection in congestive heart failure (CHF). U.S. Carvedilol Heart Failure Study with 1094 patients showed 65% lower risk of death than placebo patients 1. Dose should be started at 3.125 mg BID and titrated (as tolerated) upto 25 mg BID. Obese patients may require higher dose.Extended release Metoprolol (Toprol XL) is another B-blocker approved from FDA for use in CHF. MERIT-HF study showed 34% reduction in mortality than placebo in patients taking Toprol XL 2.

FDA approves only Toprol-XL and Coreg for CHF.


References: Click to get article/abstract

1. The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure - N Engl J Med. 1996;334:1349-1355.

2. MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomised intervention trial in congestive heart failure. Lancet. 1999;353:2001-2007

Saturday October 6, 2007
On reintubation rate

Here is a little twist if you are proud of your too low reintubation rate !!

"A reintubation rate of 5% to 15% is acceptable; lower rates indicate the patients are being kept on the ventilator too long, while higher rates suggest that they are being taken off too soon". - Dr. Neil R. Macintyre - at ACCP annual meeting, october 23, 2006


Related links:

HOW TO ESTABLISH A VENTILATOR WEANING PROTOCOL , Gregory P. Marelich, MD - thoracic.org

When to wean from a ventilator: An evidence-based strategy, Ref: CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 70, NUMBER 5 MAY 2003 page 389


Related previous pearls:

Spontaneous Breathing Trial (SBT) - how long - 30 or 120 minutes?,

IV steroid to reduces postextubation stridor

Friday October 5, 2007
Our progress card on Venous Thromboembolism Prophylaxis in Acutely Ill Hospitalized Medical Patients


"Chest" recently reported physicians' progress card on Venous Thromboembolism Prophylaxis in 15,156 Acutely Ill Hospitalized Medical Patients from 52 hospitals in 12 countries via program called IMPROVE (international Medical Prevention Registry on Venous Thromboembolism).


Results:

• Only approximately 60% of patients who either met the ACCP criteria for requiring prophylaxis or were eligible for enrollment in randomized clinical trials that have shown the benefits of pharmacologic prophylaxis actually received prophylaxis.


• Intermittent pneumatic compression was the most common form of medical prophylaxis utilized in the United States, although it was used very rarely in other countries (22% vs 0.2%, respectively).


• Unfractionated heparin was the most frequent pharmacologic approach used in the United States (21% of patients), with low-molecular-weight heparin used most frequently in other participating countries (40%).


• There was also variable use of elastic stockings in the United States and other participating countries (3% vs 7%, respectively.

Conclusions; Data suggest that physicians’ practices for providing VTE prophylaxis to acutely ill hospitalized medical patients are suboptimal.




Reference: click to get article

1. Venous Thromboembolism Prophylaxis in Acutely Ill Hospitalized Medical Patients - Chest. 2007; 132:936-945

Thursday October 4, 2007
Hypothermia and hypocapnia !

Editors' note: Many time objective of our pearls is to introduce concepts which may be only of academic interest but intensivist need to be atleast aware of it.


Q: What's the relationship of CO2 production with level of hypothermia?

A: For every degree below 37 c, CO2 production decrease approximately by 10%, due to decrease metabolic demand. During post-operative warming, it should be kept in mind, anticipating rise in CO2 while weaning ventilator.

Wednesday October 3, 2007
Rocephin and calcium !


The safety labeling for IV ceftriaxone (Rocephin) has been updated by FDA to describe the potential risks associated with concomitant use of calcium or calcium-containing solutions in patients of any age (despite most reports are from neonates).

Per Roche, the maker of Rocephin, "the theoretical possibility exists for an interaction between ceftriaxone and IV calcium-containing solutions in patients other than neonates." Therefore, the use of ceftriaxone with calcium products is now contraindicated in all age groups.

Cases of fatal reactions with calcium-ceftriaxone precipitates in the lungs and kidneys have been reported in both term and premature neonates. Some of these cases occurred even when ceftriaxone and the calcium-containing products were administered by different routes at different times.

Because of the risk for particulate precipitation, ceftriaxone should not be mixed with calcium-containing solutions/products or reconstituted with calcium-containing diluents such as Ringer's or Hartmann's solution. Concomitant administration of ceftriaxone with calcium-containing solutions or products is likewise contraindicated, even via different infusion lines; 48 hours should elapse between the last dose of ceftriaxone and their use.


Reference: click to get article/abstract

1. IMPORTANT CLARIFICATION OF PRESCRIBING INFORMATION, fda - medwatch - Ceftriazone - August 2007

Tuesday October 2, 2007
Ethanol drip in Ethylene Glycol


Q; How you write Ethanol drip in Ethylene Glycol poisoning assuming you don't have Fomepizole or Dialysis available ?


A: Ethylene Glycol poisoning is common and can have bleak outcomes. Intensivists should be aware of all the possible interventions available. Antidotal therapy is based on preventing the alcohol dehydrogenase enzyme from metabolizing ethylene glycol into toxic byproducts. In case Fomepizole or Dialysis is not available, Ethanol will competitively inhibit alcohol dehydrogenase. But the serum ethanol level must be monitored frequently.Therapeutic ethanol is administered in a bolus followed by a continuous infusion. Initially, 7.5 to 10 mL/Kg of 10% ethanol, in D5W, is administered over 30 minutes. Then, a continuous infusion of 1 to 2 mL/Kg/hr of 10% ethanol is infused until the patient has eliminated all of the EG from his serum. It is important to keep the serum ethanol level at 100 to 150 mg/dL so as to completely inhibit the alcohol dehydrogenase enzyme.

Actual antidote or first line therapy is Fomepizole (Antizol) with fewer side effects. Fomepizole blocks alcohol dehydrogenase. Fomepizole is administered as 15 mg/Kg (up to 1 Gm) initially, then 10 mg/Kg q12h times four doses, and then 15 mg/Kg q12 hours until ethylene glycol level <10>


Bonus Pearl: Fomepizole can also be use as an antidote in Methanol overdose.

Monday October 1, 2007

Scenario: A patient was transferred to Critical Care Unit in septic shock. 4 out of 4 blood cultures were positive for Staphylococcus epidermidis and E. coli. Patient moved from Mexico to United States approximately six months ago for the treatment of HTLV-1 associated Lymphoma and has been on chemotherapy. What is the most likely cause of sepsis?

Diagnosis: Strongyloidiasis.

Strongyloides stercoralis is endemic in many areas of the world and is associated with HTLV-1. There is increased risk of disseminated strongyloides in immunocompromised individuals, and can result in pllymicrobial bacteremia.


Read very precise review article at emedicine.com: Strongyloides Stercoralis

click to get larger image

Reference: click to get abstract/article

1. A Canadian immigrant with coinfection of Strongyloides stercoralis and human T-lymphotropic virus 1 - CMAJ • August 28, 2007; 177 (5).

2. Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management - CMAJ • August 31, 2004; 171 (5).